The Accidental Discovery of Fenbendazole’s Anti-Cancer Properties

It started with a fluke. An experiment that nearly had to be scrapped.

Fenbendazole (commonly known as Fenben) is an inexpensive antiparasitic medicine found in just about every vet clinic and zoo. It wasn’t on anyone’s radar for cancer. Not until a research scientist ran into a problem with her lab mice. The mice were part of a brain tumor study, but those mice came down with a parasite infection. So she treated them with Fenbendazole.

And that’s when something strange happened.

The cancer in those mice stopped growing. The tumors simply wouldn’t take off like they usually did. At first, the scientist thought she’d messed up the study. But it turned out she’d stumbled onto something potentially life-changing. This humble little parasite medicine seemed to have a powerful effect on cancer.

How Could That Be?

As it turns out, Fenbendazole doesn’t just target parasites — it hits cancer on several fronts. Here’s what we know.

First, it helps revive your body’s natural tumor-fighting gene, called p53. Think of p53 as your internal security guard. It spots damaged cells and tells them to self-destruct before they can turn into cancer. But in many people with cancer, that system has gone offline. Fenben helps bring it back.
Second, cancer cells rely heavily on sugar to grow. It’s their favorite fuel. Fenben interferes with how they process glucose, basically cutting off their energy supply. No fuel? No fire.
And finally, it messes with microtubules — the tiny scaffolding inside cells that cancer uses to divide and spread. By destabilizing those structures, Fenben throws a wrench in the cancer’s growth engine.

Could Parasites Be the Missing Piece?

Most people think of parasites as a third-world problem. But parasites are more common here in the U.S. than we would like to admit — lurking in soil, tap water, and even your own backyard. Once inside the body, they can trigger inflammation, suppress the immune system, and create the kind of environment where cancer loves to grow.

I learned this firsthand. The renowned parasitologist Dr. Hermann Bueno told me, “I’ve never seen a single case of cancer that didn’t involve parasites.”

That one sentence stuck with me. It might explain why anti-parasitic drugs like Fenbendazole are showing so much promise. Maybe they’re doing more than fighting bugs — maybe they’re helping the body finally do what it was meant to do: heal.

No, this isn’t a miracle drug. And I’d never suggest you drop everything and take it without doing your homework and checking with your healthcare practitioner. But when survivors speak, and the science begins to line up with their stories — you’d better believe I’m paying attention.

How Does Fenbendazole Actually Work?

If you’re wondering how a dog dewormer could possibly fight cancer, you’re not alone. The answer lies in how Fenbendazole (or Fenben, as many call it) interacts with the body — and more importantly, with cancer cells.

One of its biggest strengths? Fenben helps wake up your body’s natural defense system. There’s a special protein in your cells called p53 — often called the “guardian of the genome.” Its job is to spot damaged cells and tell them, “Time’s up,” before they turn into cancer. But in many cancer patients, this gene is either asleep or broken. Fenben seems to help bring it back online, which is a game-changer.

It doesn’t stop there.

Cancer cells are sugar addicts. They depend on glucose for fuel — and they burn through it like wildfire. Fenben throws a wrench into their metabolic engine by blocking the pathways they use to absorb that sugar. Starved of fuel, cancer cells start to weaken and die off.

And there’s one more way Fenben interrupts the growth of cancer. It messes with microtubules, the tiny scaffolding inside cancer cells that helps them grow and divide. When Fenben destabilizes those structures, the cancer cells can’t keep multiplying. It’s like knocking out the frame of a building before it’s fully constructed.

What Do Parasites Have to Do With It?

Parasites might play a bigger role in cancer than most people think. For years, we assumed parasites were only an issue in developing countries. But that’s not the case. In the U.S., parasites can lurk in contaminated water, soil, undercooked food — even through contact with our pets. Once they’re inside the body, they can suppress the immune system, create chronic inflammation, and set the stage for bigger problems… like cancer.

That might be why Dr. Hermann Bueno, one of the world’s top parasitologists, told me, “I’ve never seen a single case of cancer that didn’t have a parasitic component.” That’s a bold claim — but it lines up with what others are beginning to notice.

Could this explain why drugs like Fenbendazole — designed to wipe out parasites — are showing such promise against cancer? The pieces start to fit together.

Joe Tippens’ Story: How A $7 Dog Medicine Beat Terminal Lung Cancer

When I first spoke with Joe Tippens, I could tell right away—this was a man who had been through something big. He had a strong voice, but underneath it, you could still hear the disbelief.

Joe’s just a regular guy from Oklahoma who got hit with some of the worst news you can imagine: stage 4 lung cancer. His doctors gave him maybe three months to live and told him to start getting his affairs in order. But then something surprising happened. A friend of his—who happened to be a vet—told him about a strange study where lab mice with cancer were completely cured. The secret? A cheap dog dewormer called Fenbendazole. It sounded crazy. But with nothing left to lose, Joe decided to try it.

It wasn’t long before that combination would be known around the world as the Joe Tippens Protocol. The result? Just over three months later, a scan showed something that stunned everyone — no cancer. None. Joe was floored. His doctors were speechless. And Joe’s story was just beginning.

Cancer Survivor Sharon McDougall: From Stage 4 Colon Cancer to No Malignancy Found

Sharon McDougall, a registered nurse diagnosed with Stage 4 Colon Cancer, was preparing for the end of her life until she discovered the Joe Tippens Protocol. After incorporating Fenbendazole into her regimen, a scan just a few months later showed no signs of malignancy, leading to an astonishing recovery. Learn more about her story HERE.

Is Fenbendazole Right for You?

Fenbendazole’s potential as a repurposed, inexpensive drug offers a unique and accessible option for those seeking alternative or complementary cancer treatments.

Before incorporating Fenbendazole into your cancer protocol, you’ll want to thoroughly research and weigh the options to make the best decision for your health. While it has shown promising results, each individual’s situation is unique, and what works for one person may not be suitable for another. Always consult with a trusted healthcare professional to ensure that any potential treatment plan aligns with your specific needs and circumstances.

Resources:

Duan Q, Liu Y, Rockwell S. Fenbendazole as a potential anticancer drug. Anticancer Res. 2013 Feb;33(2):355-62. PMID: 23393324; PMCID: PMC3580766.

(Mebendazole): Bai RY, Staedtke V, Aprhys CM, Gallia GL, Riggins GJ. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol. 2011 Sep;13(9):974-82. doi: 10.1093/neuonc/nor077. Epub 2011 Jul 15. PMID: 21764822; PMCID: PMC3158014.

Dogra N, Kumar A, Mukhopadhyay T. Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Sci Rep. 2018 Aug 9;8(1):11926. doi: 10.1038/s41598-018-30158-6. PMID: 30093705; PMCID: PMC6085345.

Park D, Lee JH, Yoon SP. Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells. Korean J Physiol Pharmacol. 2022 Sep 1;26(5):377-387. doi: 10.4196/kjpp.2022.26.5.377. PMID: 36039738; PMCID: PMC9437363.

Semkova S, Nikolova B, Tsoneva I, Antov G, Ivanova D, Angelov A, Zhelev Z, Bakalova R. Redox-mediated Anticancer Activity of Anti-parasitic Drug Fenbendazole in Triple-negative Breast Cancer Cells. Anticancer Res. 2023 Mar;43(3):1207-1212. doi: 10.21873/anticanres.16267. PMID: 36854536.

Elayapillai S, Ramraj S, Benbrook DM, Bieniasz M, Wang L, Pathuri G, Isingizwe ZR, Kennedy AL, Zhao YD, Lightfoot S, Hunsucker LA, Gunderson CC. Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer. Gynecol Oncol. 2021 Jan;160(1):302-311. doi: 10.1016/j.ygyno.2020.10.010. Epub 2020 Oct 31. PMID: 33131904; PMCID: PMC8820236.

Cray C, Altman NH. An Update on the Biologic Effects of Fenbendazole. Comp Med. 2022 Aug 1;72(4):215-219. doi: 10.30802/AALAS-CM-22-000006. Epub 2022 Jun 28. PMID: 35764389; PMCID: PMC9413524.

Sultana T, Jan U, Lee JI. Double Repositioning: Veterinary Antiparasitic to Human Anticancer. Int J Mol Sci. 2022 Apr 13;23(8):4315. doi: 10.3390/ijms23084315. PMID: 35457127; PMCID: PMC9029030.

Gao P, Dang CV, Watson J. Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. J Am Assoc Lab Anim Sci. 2008 Nov;47(6):37-40. PMID: 19049251; PMCID: PMC2687140.

Meco D, Attinà G, Mastrangelo S, Navarra P, Ruggiero A. Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers. Int J Mol Sci. 2023 Jan 10;24(2):1334. doi: 10.3390/ijms24021334. PMID: 36674870; PMCID: PMC9862092.

Johns Hopkins Medicine: Surprise Finding Yields a Possible Tumor-Fighting Drug (Nov 11, 2014)

News Release: Johns Hopkins Study: Anti-Parasitic Drug Slows Pancreatic Cancer in Mice (Aug 3 2021)